Publications

  • 1. Bhagat TD, Von Ahrens D, Dawlaty M, Zou Y, Baddour J, Achreja A, Zhao H, Yang L, Patel B, Kwak C, Choudhary GS, Gordon-Mitchell S, Aluri S, Bhattacharyya S, Sahu S, Bhagat P, Yu Y, Bartenstein M, Giricz O, Suzuki M, Sohal D, Gupta S, Guerrero PA, Batra S, Goggins M, Steidl U, Greally J, Agarwal B, Pradhan K, Banerjee D, Nagrath D, Maitra A, Verma A.Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts. Elife. 2019 Nov 1;8. pii: e50663. PMID: 31663852 PMCID: PMC6874475 DOI: 10.7554/eLife.50663
  • 2. Sulahian R, Kwon JJ, Walsh KH, Pailler E, Bosse TL, Thaker M, Almanza D, Dempster JM, Pan J, Piccioni F, Dumont N, Gonzalez A, Rennhack J, Nabet B, Bachman JA, Goodale A, Lee Y, Bagul M, Liao R, Navarro A, Yuan TL, Ng RWS, Raghavan S, Gray NS, Tsherniak A, Vazquez F, Root DE, Firestone AJ, Settleman J, Hahn WC, Aguirre AJ. Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Cell Rep. 2019 Oct 1;29(1):118-134.e8. PMID: 31577942 PMCID: PMC6918830 DOI: 10.1016/j.celrep.2019.08.090
  • 3. Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, Kikuchi H, Mamessier E, Aoki S, Ramjiawan RR, Ochiai H, Bardeesy N, Huang P, Cobbold M, Zhu AX, Jain RK, Duda DG. Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma. Hepatology. 2019 Aug 5. PMID: 31378984 DOI: 10.1002/hep.30889
  • 4. Halbrook CJ1, Crawford HC2,3,4. Hiding in plain sight. Science. 2019 Jun 21;364(6446):1132-1133. PMID: 31221844 PMCID: PMC6709523 DOI: 10.1126/science.aax9341
  • 5. Aguirre AJ. Oncogenic NRG1 Fusions: A New Hope for Targeted Therapy in Pancreatic Cancer. Clin Cancer Res. 2019 Aug 1;25(15):4589-4591. Epub 2019 Jun 4. PMID: 31164372 PMCID: PMC6679796 DOI: 10.1158/1078-0432.CCR-19-1280.
  • 6. Stone ML, Beatty GL. Cellular determinants and therapeutic implications of inflammation in pancreatic cancer. Pharmacol Ther. 2019 Sep;201:202-213. PMID: 31158393 PMCID: PMC6708742 DOI: 10.1016/j.pharmthera.2019.05.012
  • 7. Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, Ferrone CR, Parikh AR, Weekes CD, Nipp RD, Kwak EL, Allen JN, Corcoran RB, Ting DT, Faris JE, Zhu AX, Goyal L, Berger DL, Qadan M, Lillemoe KD, Talele N, Jain RK, DeLaney TF, Duda DG, Boucher Y, Fernández-Del Castillo C, Hong TS. Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial. JAMA Oncol. 2019 May 30. PMID: 31145418 PMCID: PMC6547247 DOI: 10.1001/jamaoncol.2019.0892
  • 8. Wen HJ, Gao S, Wang Y, Ray M, Magnuson MA, Wright CVE, Di Magliano MP, Frankel TL, Crawford HC. Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;8(2):173-192. PMID: 31125624 PMCID: PMC6661420 DOI: 10.1016/j.jcmgh.2019.05.006
  • 9. Datta M, Coussens LM, Nishikawa H, Hodi FS, Jain RK. Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies. Am Soc Clin Oncol Educ Book. 2019 Jan;39:165-174. PMID: 31099649 PMCID: PMC6596289 [Available on 2019-11-17] DOI: 10.1200/EDBK_237987
  • 10. Amoozgar Z, Jain RK, Duda DG. Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System?. Cancer Res. 2019 May 1;79(9):2104-2106.PMID: 31043429 PMCID: PMC6601607 [Available on 2019-11-01] DOI: 10.1158/0008-5472.CAN-19-0749
  • 11. Dougan M, Dranoff G, Dougan SK. GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation. Immunity. 2019 Apr 16;50(4):796-811. doi: 10.1016/j.immuni.2019.03.022. PMID: 30995500 DOI: 10.1016/j.immuni.2019.03.022
  • 12. Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nat Biomed Eng. 2019 Mar;3(3):230-245. PMID: 30948807 PMCID: PMC6452896 DOI: 10.1038/s41551-018-0334-7
  • 13. Cleary JM, Horick NK, McCleary NJ, Abrams TA, Yurgelun MB, Azzoli CG, Rubinson DA, Brooks GA, Chan JA, Blaszkowsky LS, Clark JW, Goyal L, Meyerhardt JA, Ng K, Schrag D, Savarese DMF, Graham C, Fitzpatrick B, Gibb KA, Boucher Y, Duda DG, Jain RK, Fuchs CS, Enzinger PC,. FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial. Cancer. 2019 Mar 26. doi: 10.1002/cncr.32029. PMID: 30913304 PMCID: PMC6763367 DOI: 10.1002/cncr.32029
  • 14. Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA. Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.Cell Metab. 2019 Jun4;29(6):1390-1399.e6. doi: 10.1016/j.cmet.2019.02.001. Epub 2019 Feb 28. PMID: 30827862 PMCID: PMC6602533 DOI: 10.1016/j.cmet.2019.02.001
  • 15. Martin JD, Seano G, Jain RK. Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges. Annu Rev Physiol. 2019 Feb 10;81:505-534. PMID: 30742782 PMCID: PMC6571025 DOI: 10.1146/annurev-physiol-020518-114700
  • 16. Whittle MC, Hingorani SR. Fibroblasts in Pancreatic Ductal Adenocarcinoma: Biological Mechanisms and Therapeutic Targets. Gastroenterology. 2019 Feb 2. pii: S0016-5085(19)30359-2. PMID: 30721663 PMCID: PMC6486863 [Available on 2020-05-01] DOI: 10.1053/j.gastro.2018.12.044
  • 17. Crawford HC, Pasca di Magliano M, Banerjee S. Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis. Gastroenterology. 2019 Feb 1. pii: S0016-5085(19)30351-8. PMID: 30716326 PMCID: PMC6545585 DOI: 10.1053/j.gastro.2018.12.042
  • 18. Chen IX, Chauhan VP, Posada J, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK. Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer. Proc Natl Acad Sci U S A. 2019 Jan 30. pii: 201815515. PMID: 30700545 PMCID: PMC6410779 DOI: 10.1073/pnas.1815515116
  • 19. Balachandran VP, Beatty GL, Dougan SK. Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities. Gastroenterology. 2019 May;156(7):2056-2072. PMID: 30660727 PMCID: PMC6486864 [Available on 2020-05-01] DOI: 10.1053/j.gastro.2018.12.038
  • 20. Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, Yeku O, Del Carmen MG, Spriggs DR, Jain RK, Xu L. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2210-2219. PMID: 30659155 PMCID: PMC6369817 DOI: 10.1073/pnas.1818357116
  • 21. Nia HT, Munn LL, Jain RK. Mapping Physical Tumor Microenvironment and Drug Delivery. Clin Cancer Res. 2019 Apr 1;25(7):2024-2026. PMID: 30630829 PMCID: PMC6445672 DOI: 10.1158/1078-0432.CCR-18-3724
  • 22. Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L. A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. Nat Protoc. 2019 Feb;14(2):541-555. PMID: 30617350 PMCID: PMC6571021 DOI: 10.1038/s41596-018-0105-7
  • 23. Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018 Dec 18;49(6):1148-1161.e7. PMID: 30552023 PMCID: PMC6301092 DOI: 10.1016/j.immuni.2018.09.024
  • 24. Aguirre AJ. Refining Classification of Pancreatic Cancer Subtypes to Improve Clinical Care. Gastroenterology. 2018 Dec;155(6):1689-1691. PMID: 30419209 DOI: 10.1053/j.gastro.2018.11.004
  • 25. Goggins MG, Lippman SM, Constantinou PE, Jacks T, Petersen GM, Syngal S, Maitra A. Intercepting Pancreatic Cancer: Our Dream Team's Resolve to Stop Pancreatic Cancer. Pancreas. 2018 Nov/Dec;47(10):1175-1176. PMID: 30325853 PMCID: PMC6193263 DOI: 10.1097/MPA.0000000000001165
  • 26. Yasmin-Karim S, Bruck PT, Moreau M, Kunjachan S, Chen GZ, Kumar R, Grabow S, Dougan SK, Ngwa W. Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer. Front Immunol. 2018 Sep 7;9:2030. PMID: 30245691 PMCID: PMC6137176 DOI: 10.3389/fimmu.2018.02030
  • 27. Khandekar MJ, Jain R. Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study. Transl Cancer Res. 2018 Feb;7(Suppl 1):S16-S20. PMID: 30175050 PMCID: PMC6117158 DOI: 10.21037/tcr.2017.12.17
  • 28. Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D, McDannold N, Jain RK. Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8717-E8726. PMID: 30150398 PMCID: PMC6140479 DOI: 10.1073/pnas.1807105115
  • 29. Aguirre AJ, Nowak JA, Camarda ND, Moffitt RA, Ghazani AA, Hazar-Rethinam M, Raghavan S, Kim J, Brais LK, Ragon D, Welch MW, Reilly E, McCabe D, Marini L, Anderka K, Helvie K, Oliver N, Babic A, Da Silva A, Nadres B, Van Seventer EE, Shahzade HA, St Pierre JP, Burke KP, Clancy T, Cleary JM, Doyle LA, Jajoo K, McCleary NJ, Meyerhardt JA, Murphy JE, Ng K, Patel AK, Perez K, Rosenthal MH, Rubinson DA, Ryou M, Shapiro GI, Sicinska E, Silverman SG, Nagy RJ, Lanman RB, Knoerzer D, Welsch DJ, Yurgelun MB, Fuchs CS, Garraway LA, Getz G, Hornick JL, Johnson BE, Kulke MH, Mayer RJ, Miller JW, Shyn PB, Tuveson DA, Wagle N, Yeh JJ, Hahn WC, Corcoran RB, Carter SL, Wolpin BM. Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine. Cancer Discov. 2018 Sep;8(9):1096-1111. PMID: 29903880 PMCID: PMC6192263 DOI: 10.1158/2159-8290.CD-18-0275
  • 30. Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RK. Quantifying solid stress and elastic energy from excised or in situ tumors. Nat Protoc. 2018 May;13(5):1091-1105. PMID: 29674756 PMCID: PMC6546092 DOI: 10.1038/nprot.2018.020
  • 31. Carr JA, Franke D, Caram JR, Perkinson CF, Saif M, Askoxylakis V, Datta M, Fukumura D, Jain RK, Bawendi MG, Bruns OT. Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4465-4470. PMID: 29626132 PMCID: PMC5924901 DOI: 10.1073/pnas.1718917115
  • 32. Pinter M, Kwanten WJ, Jain RK. Renin-Angiotensin System Inhibitors to Mitigate Cancer Treatment-Related Adverse Events. Clin Cancer Res. 2018 Aug 15;24(16):3803-3812. PMID: 29610292 PMCID: PMC6095804 DOI: 10.1158/1078-0432.CCR-18-0236
  • 33. Stylianopoulos T, Munn LL, Jain RK. Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. Trends Cancer. 2018 Apr;4(4):292-319. PMID: 29606314 PMCID: PMC5930008 DOI: 10.1016/j.trecan.2018.02.005
  • 34. Puré E, Hingorani SR. Mesenchymal Cell Plasticity and Perfidy in Epithelial Malignancy. Trends Cancer. 2018 Apr;4(4):273-277. PMID: 29606311 DOI: 10.1016/j.trecan.2018.02.007
  • 35. Stylianopoulos T, Munn LL, Jain RK. Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy. Trends Cancer. 2018 Apr;4(4):258-259. PMID: 29606306 PMCID: PMC6161778 DOI: 10.1016/j.trecan.2018.02.010
  • 36. Jain RK, Batista A. A Physical View of Cancer. Trends Cancer. 2018 Apr;4(4):257. PMID: 29606305 PMCID: PMC6296379 DOI: 10.1016/j.trecan.2018.03.001
  • 37. Halbrook CJ, Pasca di Magliano M, Lyssiotis CA. Tumor cross-talk networks promote growth and support immune evasion in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G27-G35. PMID: 29543507 PMCID: PMC6109710 DOI: 10.1152/ajpgi.00416.2017
  • 38. Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK. Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat Rev Clin Oncol. 2018 May;15(5):325-340. PMID: 29508855 PMCID: PMC5921900 DOI: 10.1038/nrclinonc.2018.29
  • 39. Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH, Ploegh HL, Dougan SK. Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1-Specific VHHs. Cancer Immunol Res. 2018 Apr;6(4):389-401. PMID: 29459478 PMCID: PMC6079513 DOI: 10.1158/2326-6066.CIR-17-0495
  • 40. Zhao Y, Liu P, Zhang N, Chen J, Landegger LD, Wu L, Zhao F, Zhao Y, Zhang Y, Zhang J, Fujita T, Stemmer-Rachamimov A, Ferraro GB, Liu H, Muzikansky A, Plotkin SR, Stankovic KM, Jain RK, Xu L. Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2077-E2084. PMID: 29440379 PMCID: PMC5834719 DOI: 10.1073/pnas.1719966115
  • 41. Zhang N, Chen J, Ferraro GB, Wu L, Datta M, Jain RK, Plotkin SR, Stemmer-Rachamimov A, Xu L. Anti-VEGF treatment improves neurological function in tumors of the nervous system. Exp Neurol. 2018 Jan;299(Pt B):326-333. PMID: 28911884 DOI: 10.1016/j.expneurol.2017.09.008
  • 42. Pinter M, Weinmann A, Wörns MA, Hucke F, Bota S, Marquardt JU, Duda DG, Jain RK, Galle PR, Trauner M, Peck-Radosavljevic M, Sieghart W. Use of inhibitors of the renin-angiotensin system is associated with longer survival in patients with hepatocellular carcinoma. United European Gastroenterol J. 2017 Nov;5(7):987-996. PMID: 29163965 PMCID: PMC5676550 DOI: 10.1177/2050640617695698
  • 43. Mitchell MJ, Jain RK, Langer R. Engineering and physical sciences in oncology: challenges and opportunities. Nat Rev Cancer. 2017 Nov;17(11):659-675. PMID: 29026204 PMCID: PMC5683724 DOI: 10.1038/nrc.2017.83
  • 44. Pinter M, Jain RK. Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy. Sci Transl Med. 2017 Oct 4;9(410). pii: eaan5616. PMID: 28978752 PMCID: PMC5928511 DOI: 10.1126/scitranslmed.aan5616
  • 45. Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, Ryan DP, Deshpande V, Lillemoe KD, Fernandez-Del Castillo C, Downes M, Evans RM, Michaelson J, Ferrone CR, Boucher Y, Jain RK. Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2017 Oct 1;23(19):5959-5969. PMID: 28600474 PMCID: PMC5856249 DOI: 10.1158/1078-0432.CCR-17-0256
January 31, 2020