Publications

  • 1. Singh H, Perez K, Wolpin BM, Aguirre AJ. Beyond the Front Line: Emerging Data for Maintenance Therapy in Pancreatic Cancer. J Clin Oncol. 2021 Oct 10;39(29):3199-3206. doi: 10.1200/JCO.21.01510. Epub 2021 Aug 24. PMID: 34428095; PMCID: PMC8500570.
  • 2. Crawford HC. Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation. Genes Dev. 2021 Oct 1;35(19-20):1325-1326. doi: 10.1101/gad.348971.121. PMID: 34599002; PMCID: PMC8494204.
  • 3. Bravi B, Balachandran VP, Greenbaum BD, Walczak AM, Mora T, Monasson R, Cocco S. Probing T-cell response by sequence-based probabilistic modeling. PLoS Comput Biol. 2021 Sep 2;17(9):e1009297. doi: 10.1371/journal.pcbi.1009297. PMID: 34473697; PMCID: PMC8476001.
  • 4. Kemp SB, Carpenter ES, Steele NG, Donahue KL, Nwosu ZC, Pacheco A, Velez-Delgado A, Menjivar RE, Lima F, The S, Espinoza CE, Brown K, Long D, Lyssiotis CA, Rao A, Zhang Y, Pasca di Magliano M, Crawford HC. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer Res. 2021 Aug 15;81(16):4305-4318. doi: 10.1158/0008-5472.CAN-20-3929. Epub 2021 May 28. PMID: 34049975; PMCID: PMC8445065.
  • 5. Pelissier Vatter FA, Cioffi M, Hanna SJ, Castarede I, Caielli S, Pascual V, Matei I, Lyden D. Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses. J Exp Med. 2021 Aug 2;218(8):e20202579. doi: 10.1084/jem.20202579. Epub 2021 Jun 28. PMID: 34180950; PMCID: PMC8241538.
  • 6. Dai C, Rennhack JP, Arnoff TE, Thaker M, Younger ST, Doench JG, Huang AY, Yang A, Aguirre AJ, Wang B, Mun E, O'Connell JT, Huang Y, Labella K, Talamas JA, Li J, Ilic N, Hwang J, Hong AL, Giacomelli AO, Gjoerup O, Root DE, Hahn WC. SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization. Cell Rep. 2021 Jul 27;36(4):109443. doi: 10.1016/j.celrep.2021.109443. PMID: 34320363; PMCID: PMC8350598.
  • 7. Stone ML, Lee J, Herrera VM, Graham K, Lee JW, Huffman A, Coho H, Tooker E, Myers MI, Giannone M, Li Y, Buckingham TH, Long KB, Beatty GL. TNF blockade uncouples toxicity from antitumor efficacy induced with CD40 chemoimmunotherapy. JCI Insight. 2021 Jul 22;6(14):e146314. doi: 10.1172/jci.insight.146314. PMID: 34101617; PMCID: PMC8410039.
  • 8. Beatty GL, Werba G, Lyssiotis CA, Simeone DM. The biological underpinnings of therapeutic resistance in pancreatic cancer. Genes Dev. 2021 Jul 1;35(13-14):940-962. doi: 10.1101/gad.348523.121. Epub 2021 Jun 11. PMID: 34117095; PMCID: PMC8247606.
  • 9. Rojas LA, Balachandran VP. Scaling the immune incline in PDAC. Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):453-454. doi: 10.1038/s41575-021-00475-9. PMID: 34083798; PMCID: PMC8173858.
  • 10. Ling Huang, Ridhdhi Desai, Daniel N Conrad, Nayara C Leite, Dipikaa Akshinthala, Christine Maria Lim, Raul Gonzalez, Lakshmi B Muthuswamy, Zev Gartner, Senthil K Muthuswamy. Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. Cell Stem Cell. 2021 Jun 3;28(6):1090-1104.e6. doi: 10.1016/j.stem.2021.03.022. Epub 2021 Apr 28. PMID: 33915081. PMCID: PMC8202734
  • 11. S Dhara, S Chhangawala, H Chintalapudi, G Askan, V Aveson, A L Massa, L Zhang, D Torres, A P Makohon-Moore, N Lecomte, J P Melchor, J Bermeo, A Cardenas, S Sinha, D Glassman, R Nicolle, R Moffitt, K H Yu, S Leppanen, S Laderman, B Curry, J Gui, V P Balachandran, C Iacobuzio-Donahue, R Chandwani, C S Leslie, S D Leach. Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility. Nat Commun. 2021 May 24;12(1):3044. doi: 10.1038/s41467-021-23237-2. PMID: 34031415.PMCID: PMC8144607
  • 12. 63. Roehle K, Qiang L, Ventre KS, Heid D, Ali LR, Lenehan P, Heckler M, Crowley SJ, Stump CT, Ro G, Godicelj A, Bhuiyan AM, Yang A, Quiles Del Rey M, Biary T, Luoma AM, Bruck PT, Tegethoff JF, Nopper SL, Li J, Byrne KT, Pelletier M, Wucherpfennig KW, Stanger BZ, Akin JJ, Mancias JD, Agudo J, Dougan M, Dougan SK. cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes. Sci Transl Med. 2021 May 19;13(594):eabf5058. PMID: 34011631 DOI: 10.1126/scitranslmed.abf5058
  • 13. Jimmy A Guo, Hannah I Hoffman, Stuti G Shroff, Peter Chen, Peter G Hwang, Daniel Y Kim, Daniel W Kim, Stephanie W Cheng, Daniel Zhao, Brandon A Mahal, Mohammed Alshalalfa, Andrzej Niemierko, Jennifer Y Wo, Jay S Loeffler, Carlos Fernandez-Del Castillo, Tyler Jacks, Andrew J Aguirre, Theodore S Hong, Mari Mino-Kenudson, William L Hwang. Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection. Clin Cancer Res. 2021 May 15;27(10):2807-2815. doi: 10.1158/1078-0432.CCR-20-4382. Epub 2021 Feb 25. PMID: 33632928. PMCID: PMC8127360
  • 14. Nina G Steele, Giulia Biffi, Samantha B Kemp, Yaqing Zhang, Donovan Drouillard, LiJyun Syu, Yuan Hao, Tobiloba E Oni, Erin Brosnan, Ela Elyada, Abhishek Doshi, Christa Hansma, Carlos Espinoza, Ahmed Abbas, Stephanie The, Valerie Irizarry-Negron, Christopher J Halbrook, Nicole E Franks, Megan T Hoffman, Kristee Brown, Eileen S Carpenter, Zeribe C Nwosu, Craig Johnson, Fatima Lima, Michelle A Anderson, Youngkyu Park, Howard C Crawford, Costas A Lyssiotis, Timothy L Frankel, Arvind Rao, Filip Bednar, Andrzej A Dlugosz, Jonathan B Preall, David A Tuveson, Benjamin L Allen, Marina Pasca di Magliano. Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer. Clin Cancer Res. 2021 Apr 1;27(7):2023-2037. doi: 10.1158/1078-0432.CCR-20-3715. Epub 2021 Jan 25. PMID: 33495315. PMCID: PMC8026631
  • 15. Samantha B Kemp, Nina G Steele, Eileen S Carpenter, Katelyn L Donahue, Grace G Bushnell, Aaron H Morris, Stephanie The, Sophia M Orbach, Veerin R Sirihorachai, Zeribe C Nwosu, Carlos Espinoza, Fatima Lima, Kristee Brown, Alexander A Girgis, Valerie Gunchick, Yaqing Zhang, Costas A Lyssiotis, Timothy L Frankel, Filip Bednar, Arvind Rao, Vaibhav Sahai , Lonnie D Shea, Howard C Crawford, Marina Pasca di Magliano. Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages. Life Sci Alliance. 2021 Mar 29;4(6):e202000935. doi: 10.26508/lsa.202000935. Print 2021 Jun. PMID: 33782087. PMCID: PMC8091600
  • 16. Jason J Kwon, William C Hahn. A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective. Mol Cell Biol. 2021 Mar 24;41(4):e00627-20. doi: 10.1128/MCB.00627-20. Print 2021 Mar 24. PMID: 33526449. PMCID: PMC8088128
  • 17. Sara A Vayrynen, Jinming Zhang, Chen Yuan, Juha P Vayryne, Andressa Dias Costa, Hannah Williams, Vicente Morales-Oyarvide, Mai Chan Lau, Douglas A Rubinson, Richard F Dunne, Margaret M Kozak, Wenjia Wang, Diana Agostini-Vulaj, Michael G Drage, Lauren Brais, Emma Reilly, Osama Rahma, Thomas Clancy, Jiping Wang, David C Linehan, Andrew J Aguirre, Charles S Fuchs, Lisa M Coussens, Daniel T Chang, Albert C Koong, Aram F Hezel, Shuji Ogino, Jonathan A Nowak, Brian M Wolpin. Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer. Clin Cancer Res. 2021 Feb 15;27(4):1069-1081. doi: 10.1158/1078-0432.CCR-20-3141. Epub 2020 Dec 1. PMID: 33262135
  • 18. Grace G Bushnell, Sophia M Orbach, Jeffrey A Ma, Howard C Crawford, Max S Wicha, Jacqueline S Jeruss, Lonnie D Shea. Disease-induced immunomodulation at biomaterial scaffolds detects early pancreatic cancer in a spontaneous model. Biomaterials. 2021 Feb;269:120632. doi: 10.1016/j.biomaterials.2020.120632. Epub 2020 Dec 23. PMID: 33418200. PMCID: PMC7870556
  • 19. Douglas E Biancur, Kevin S Kapner, Keisuke Yamamoto, Robert S Banh, Jasper E Neggers, Albert S W Sohn, Warren Wu, Robert T Manguso, Adam Brown, David E Root, Andrew J Aguirre, Alec C Kimmelman. Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer. Cell Metab. 2021 Jan 5;33(1):199-210.e8. doi: 10.1016/j.cmet.2020.10.018. Epub 2020 Nov 4. PMID: 33152323. PMCID: PMC7790858
  • 20. Genevieve M Gerhard, Ruben Bill, Marius Messemaker, Allon M Klein, Mikael J Pittet. Tumor-infiltrating dendritic cell states are conserved across solid human cancers. J Exp Med. 2021 Jan 4;218(1):e20200264. doi: 10.1084/jem.20200264. PMID: 33601412. PMCID: PMC7754678
  • 21. Jasper E Neggers, Brenton R Paolella, Adhana Asfaw, Michael V Rothberg, Thomas A Skipper, Annan Yang, Radha L Kalekar, John M Krill-Burger, Neekesh V Dharia, Guillaume Kugener, Jeremie Kalfon, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y Li, Liam F Spurr, Westley W Wu, Adam D Durbin, Brian M Wolpin, Federica Piccioni, David E Root, Jesse S Boehm, Andrew D Cherniack, Aviad Tsherniak, Andrew L Hong, William C Hahn, Kimberly Stegmaier, Todd R Golub, Francisca Vazquez, Andrew J Aguirre. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2020 Dec 15;33(11):108493. doi: 10.1016/j.celrep.2020.108493. PMID: 33326793
  • 22. Ivy X Chen, Kathleen Newcomer, Kristen E Pauken, Vikram R Juneja, Kamila Naxerova, Michelle W Wu, Matthias Pinter, Debattama R Sen, Meromit Singe, Arlene H Sharpe, Rakesh K Jain. A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23684-23694. doi: 10.1073/pnas.2002806117. Epub 2020 Sep 9. PMID: 32907939. PMCID: PMC7519254
  • 23. Max M Wattenberg, Gregory L Beatty. Overcoming immunotherapeutic resistance by targeting the cancer inflammation cycle. Semin Cancer Biol. 2020 Oct;65:38-50. doi: 10.1016/j.semcancer.2020.01.002. Epub 2020 Jan 15. PMID: 31954172. PMCID: PMC7363515
  • 24. Holly Brunton, Ian M Garner, Ulla-Maja Bailey, Rosie Upstill-Goddard, Peter J Bailey. Using Chromatin Accessibility to Delineate Therapeutic Subtypes in Pancreatic Cancer Patient-Derived Cell Lines. STAR Protoc. 2020 Aug 4;1(2):100079. doi: 10.1016/j.xpro.2020.100079. eCollection 2020 Sep 18. PMID: 33111113.PMCID: PMC7580199
  • 25. Sammy Ferri-Borgogno, Sugata Barui, Amberly M McGee, Tamara Griffiths, Pankaj K Singh, Cortt G Piett, Bidyut Ghosh, Sanchari Bhattacharyya, Aatur Singhi, Kith Pradhan 4, Amit Verma, Zac Nagel, Anirban Maitra, Sonal Gupta. Paradoxical Role of AT-rich Interactive Domain 1A in Restraining Pancreatic Carcinogenesis. Cancers (Basel). 2020 Sep 21;12(9):2695. doi: 10.3390/cancers12092695. PMID: 32967217. PMCID: PMC7564752
  • 26. McFarland, James M; Paolella, Brenton R; Warren, Allison; Geiger-Schuller, Kathryn; Shibue, Tsukasa; Rothberg, Michael; Kuksenko, Olena; Colgan, William N; Jones, Andrew; Chambers, Emily; Dionne, Danielle; Bender, Samantha; Wolpin, Brian M; Ghandi, Mahmoud; Tirosh, Itay; Rozenblatt-Rosen, Orit; Roth, Jennifer A; Golub, Todd R; Regev, Aviv; Aguirre, Andrew J; Vazquez, Francisca; Tsherniak, Aviad. Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action. Nat Commun. 2020 Aug 27;11(1):4296. doi: 10.1038/s41467-020-17440-w. PMID: 32855387. PMCID: PMC7453022
  • 27. Hoshino, Ayuko; Kim, Han Sang; Bojmar, Linda; Gyan, Kofi Ennu; Cioffi, Michele; Hernandez, Jonathan; Zambirinis, Constantinos P; Rodrigues, Gonzalo; Molina, Henrik; Heissel, Soren; Mark, Milica Tesic; Steiner, Loic; Benito-Martin, Alberto; Lucotti, Serena; Di Giannatale, Angela; Offer, Katharine; Nakajima, Miho; Williams, Caitlin; Nogues, Laura; Pelissier Vatter, Fanny A; Hashimoto, Ayako; Davies, Alexander E; Freitas, Daniela; Kenific, Candia M; Ararso, Yonathan; Buehring, Weston; Lauritzen, Pernille; Ogitani, Yusuke; Sugiura, Kei; Takahashi, Naoko; Ale?kovi?, Ma?a; Bailey, Kayleen A; Jolissant, Joshua S; Wang, Huajuan; Harris, Ashton; Schaeffer, L Miles; Garcia-Santos, Guillermo; Posner, Zoe; Balachandran, Vinod P; Khakoo, Yasmin; Raju, G Praveen; Scherz, Avigdor; Sagi, Irit; Scherz-Shouval, Ruth; Yarden, Yosef; Oren, Moshe; Malladi, Mahathi; Petriccione, Mary; De Braganca, Kevin C; Donzelli, Maria; Fischer, Cheryl; Vitolano, Stephanie; Wright, Geraldine P; Ganshaw, Lee; Marrano, Mariel; Ahmed, Amina; DeStefano, Joe; Danzer, Enrico; Roehrl, Michael H A; Lacayo, Norman J; Vincent, Theresa C; Weiser, Martin R; Brady, Mary S; Meyers, Paul A; Wexler, Leonard H; Ambati, Srikanth R; Chou, Alexander J; Slotkin, Emily K; Modak, Shakeel; Roberts, Stephen S; Basu, Ellen M; Diolaiti, Daniel; Krantz, Benjamin A; Cardoso, Fatima; Simpson, Amber L; Berger, Michael; Rudin, Charles M; Simeone, Diane M; Jain, Maneesh; Ghajar, Cyrus M; Batra, Surinder K; Stanger, Ben Z; Bui, Jack; Brown, Kristy A; Rajasekhar, Vinagolu K; Healey, John H; de Sousa, Maria; Kramer, Kim; Sheth, Sujit; Baisch, Jeanine; Pascual, Virginia; Heaton, Todd E; La Quaglia, Michael P; Pisapia, David J; Schwartz, Robert; Zhang, Haiying; Liu, Yuan; Shukla, Arti; Blavier, Laurence; DeClerck, Yves A; LaBarge, Mark; Bissell, Mina J; Caffrey, Thomas C; Grandgenett, Paul M; Hollingsworth, Michael A; Bromberg, Jacqueline; Costa-Silva, Bruno; Peinado, Hector; Kang, Yibin; Garcia, Benjamin A; O'Reilly, Eileen M; Kelsen, David; Trippett, Tanya M; Jones, David R; Matei, Irina R; Jarnagin, William R; Lyden, David. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020 Aug 20;182(4):1044-1061.e18. doi: 10.1016/j.cell.2020.07.009. Epub 2020 Aug 13. PMID: 32795414. PMCID: PMC7522766
  • 28. John D Martin, Dan G Duda, Rakesh K Jain. Going Beyond VEGF Pathway Inhibition for Antiangiogenic Cancer Therapy: Is Inhibition of the PP2A/B55α Complex the Answer?. Circ Res. 2020 Aug 28;127(6):724-726. doi: 10.1161/CIRCRESAHA.120.317720. Epub 2020 Aug 27. PMID: 32853096. PMCID: PMC7462096
  • 29. Jeanine M Ruggeri, Janusz Franco-Barraza, Anjum Sohail, Yaqing Zhang, Daniel Long, Marina Pasca di Magliano, Edna Cukierman, Rafael Fridman, Howard C Crawford. Discoidin Domain Receptor 1 (DDR1) Is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma. Am J Pathol. 2020 Aug;190(8):1735-1751. doi: 10.1016/j.ajpath.2020.03.020. Epub 2020 Apr 24. PMID: 32339496. PMCID: PMC7416078
  • 30. Abdel N. Hosein, Rolf A. Brekken & Anirban Maitra. Pancreatic cancer stroma: an update on therapeutic targeting strategies. Nat Rev Gastroenterol Hepatol. 2020 Aug;17(8):487-505. doi: 10.1038/s41575-020-0300-1. Epub 2020 May 11. PMID: 32393771. PMCID: PMC8284850
  • 31. Arthur Brannon III, Donovan Drouillard, Nina Steele, Shadae Schoettle, Ethan V. Abel, Howard C. Crawford & Marina Pasca di Magliano. Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition. Sci Rep. 2020 Jul 7;10(1):11133. doi: 10.1038/s41598-020-67814-9. PMID: 32636409. PMCID: PMC7340786
  • 32. Storz, Peter; Crawford, Howard C. Carcinogenesis of Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2020 Jun;158(8):2072-2081. PMID: 32199881 PMCID: PMC7282937 DOI: 10.1053/j.gastro.2020.02.059
  • 33. Ferguson, Fleur M; Nabet, Behnam; Raghavan, Srivatsan; Liu, Yan; Leggett, Alan L; Kuljanin, Miljan; Kalekar, Radha L; Yang, Annan; He, Shuning; Wang, Jinhua; Ng, Raymond W S; Sulahian, Rita; Li, Lianbo; Poulin, Emily J; Huang, Ling; Koren, Jost; Dieguez-Martinez, Nora; Espinosa, Sergio; Zeng, Zhiyang; Corona, Cesear R; Vasta, James D; Ohi, Ryoma; Sim, Taebo; Kim, Nam Doo; Harshbarger, Wayne; Lizcano, Jose M; Robers, Matthew B; Muthaswamy, Senthil; Lin, Charles Y; Look, A Thomas; Haigis, Kevin M; Mancias, Joseph D; Wolpin, Brian M; Aguirre, Andrew J; Hahn, William C; Westover, Kenneth D; Gray, Nathanael S. Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol. 2020 Jun;16(6):635-643. PMID: 32251410 PMCID: PMC7246176 DOI: 10.1038/s41589-020-0506-0
  • 34. Weissleder, Ralph; Pittet, Mikael J. The expanding landscape of inflammatory cells affecting cancer therapy. Nat Biomed Eng. 2020 May;4(5):489-498. PMID: 32203281 DOI: 10.1038/s41551-020-0524-y
  • 35. Chang, Renee B; Beatty, Gregory L. The interplay between innate and adaptive immunity in cancer shapes the productivity of cancer immunosurveillance. J Leukoc Biol. 2020 Apr 9. PMID: 32272502 DOI: 10.1002/JLB.3MIR0320-475R
  • 36. Martin, John D; Cabral, Horacio; Stylianopoulos, Triantafyllos; Jain, Rakesh K. Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges. Nat Rev Clin Oncol. 2020 Apr;17(4):251-266. PMID: 32034288 DOI: 10.1038/s41571-019-0308-z
  • 37. Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, Kikuchi H, Mamessier E, Aoki S, Ramjiawan RR, Ochiai H, Bardeesy N, Huang P, Cobbold M, Zhu AX, Jain RK, Duda DG. Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma. Hepatology. 2020 Apr;71(4):1247-1261. doi: 10.1002/hep.30889. Epub 2019 Oct 14. PMID: 31378984. PMCID: PMC7000304
  • 38. Millar, David G; Ramjiawan, Rakesh R; Kawaguchi, Kosuke; Gupta, Nisha; Chen, Jiang; Zhang, Songfa; Nojiri, Takashi; Ho, William W; Aoki, Shuichi; Jung, Keehoon; Chen, Ivy; Shi, Feng; Heather, James M; Shigeta, Kohei; Morton, Laura T; Sepulveda, Sean; Wan, Li; Joseph, Ricky; Minogue, Eleanor; Khatri, Ashok; Bardia, Aditya; Ellisen, Leif W; Corcoran, Ryan B; Hata, Aaron N; Pai, Sara I; Jain, Rakesh K; Fukumura, Dai; Duda, Dan G; Cobbold, Mark. Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy. Nat Biotechnol. 2020 Apr;38(4):420-425. PMID: 32042168 DOI: 10.1038/s41587-019-0404-8
  • 39. Perusina Lanfranca, Mirna; Zhang, Yaqing; Girgis, Alexander; Kasselman, Samantha; Lazarus, Jenny; Kryczek, Illona; Delrosario, Lawrence; Rhim, Andrew; Koneva, Lada; Sartor, Maureen; Sun, Lei; Halbrook, Christopher; Nathan, Hari; Shi, Jiaqi; Crawford, Howard C; Pasca di Magliano, Marina; Zou, Weiping; Frankel, Timothy L. Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice. Gastroenterology. 2020 Apr;158(5):1417-1432.e11. PMID: 31843590 PMCID: PMC7197347 DOI: 10.1053/j.gastro.2019.12.010
  • 40. Dey, Prasenjit; Li, Jun; Zhang, Jianhua; Chaurasiya, Surendra; Strom, Anders; Wang, Huamin; Liao, Wen-Ting; Cavallaro, Frederick; Denz, Parker; Bernard, Vincent; Yen, Er-Yen; Genovese, Giannicola; Gulhati, Pat; Liu, Jielin; Chakravarti, Deepavali; Deng, Pingna; Zhang, Tingxin; Carbone, Federica; Chang, Qing; Ying, Haoqiang; Shang, Xiaoying; Spring, Denise J; Ghosh, Bidyut; Putluri, Nagireddy; Maitra, Anirban; Wang, Y Alan; DePinho, Ronald A. Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment. Cancer Discov. 2020 Apr;10(4):608-625. PMID: 32046984 PMCID: PMC7125035 DOI: 10.1158/2159-8290.CD-19-0297
  • 41. Sahai, Erik; Astsaturov, Igor; Cukierman, Edna; DeNardo, David G; Egeblad, Mikala; Evans, Ronald M; Fearon, Douglas; Greten, Florian R; Hingorani, Sunil R; Hunter, Tony; Hynes, Richard O; Jain, Rakesh K; Janowitz, Tobias; Jorgensen, Claus; Kimmelman, Alec C; Kolonin, Mikhail G; Maki, Robert G; Powers, R Scott; Pur , Ellen; Ramirez, Daniel C; Scherz-Shouval, Ruth; Sherman, Mara H; Stewart, Sheila; Tlsty, Thea D; Tuveson, David A; Watt, Fiona M; Weaver, Valerie; Weeraratna, Ashani T; Werb, Zena. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020 Mar;20(3):174-186. PMID: 31980749 PMCID: PMC7046529 DOI: 10.1038/s41568-019-0238-1
  • 42. Zhang, Yaqing; Lazarus, Jenny; Steele, Nina G; Yan, Wei; Lee, Ho-Joon; Nwosu, Zeribe C; Halbrook, Christopher J; Menjivar, Rosa E; Kemp, Samantha B; Sirihorachai, Veerin R; Velez-Delgado, Ashley; Donahue, Katelyn; Carpenter, Eileen S; Brown, Kristee L; Irizarry-Negron, Valerie; Nevison, Anna C; Vinta, Alekya; Anderson, Michelle A; Crawford, Howard C; Lyssiotis, Costas A; Frankel, Timothy L; Bednar, Filip; Pasca di Magliano, Marina. Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis. Cancer Discov. 2020 Mar;10(3):422-439. PMID: 31911451 PMCID: PMC7224338 DOI: 10.1158/2159-8290.CD-19-0958
  • 43. Thomas, Stacy K; Lee, Jesse; Beatty, Gregory L. Paracrine and cell autonomous signalling in pancreatic cancer progression and metastasis. EBioMedicine. 2020 Mar;53:102662. PMID: 32139180 PMCID: PMC7118576 DOI: 10.1016/j.ebiom.2020.102662
  • 44. Ma, Ying; Li, Jun; Wang, Huamin; Chiu, Yulun; Kingsley, Charles V; Fry, David; Delaney, Samantha N; Wei, Spencer C; Zhang, Jianhua; Maitra, Anirban; Yee, Cassian. Combination of PD-1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer. Gastroenterology. 2020 Mar 14;S0016-5085(20)30339-5. PMID: 32179091 DOI: 10.1053/j.gastro.2020.03.018
  • 45. Seano, Giorgio; Jain, Rakesh K. Vessel co-option in glioblastoma: emerging insights and opportunities. Angiogenesis. 2020 Feb;23(1):9-16. PMID: 31679081 PMCID: PMC7012982 DOI: 10.1007/s10456-019-09691-z
  • 46. Crawford, Howard C; Wallace, Michael B; Storz, Peter. Early detection and imaging strategies to reveal and target developing pancreatic cancer. Expert Rev Anticancer Ther. 2020 Feb;20(2):81-83. PMID: 31986932 DOI: 10.1080/14737140.2020.1720654
  • 47. Bhagat TD, Von Ahrens D, Dawlaty M, Zou Y, Baddour J, Achreja A, Zhao H, Yang L, Patel B, Kwak C, Choudhary GS, Gordon-Mitchell S, Aluri S, Bhattacharyya S, Sahu S, Bhagat P, Yu Y, Bartenstein M, Giricz O, Suzuki M, Sohal D, Gupta S, Guerrero PA, Batra S, Goggins M, Steidl U, Greally J, Agarwal B, Pradhan K, Banerjee D, Nagrath D, Maitra A, Verma A.Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts. Elife. 2019 Nov 1;8. pii: e50663. PMID: 31663852 PMCID: PMC6874475 DOI: 10.7554/eLife.50663
  • 48. Sulahian R, Kwon JJ, Walsh KH, Pailler E, Bosse TL, Thaker M, Almanza D, Dempster JM, Pan J, Piccioni F, Dumont N, Gonzalez A, Rennhack J, Nabet B, Bachman JA, Goodale A, Lee Y, Bagul M, Liao R, Navarro A, Yuan TL, Ng RWS, Raghavan S, Gray NS, Tsherniak A, Vazquez F, Root DE, Firestone AJ, Settleman J, Hahn WC, Aguirre AJ. Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Cell Rep. 2019 Oct 1;29(1):118-134.e8. PMID: 31577942 PMCID: PMC6918830 DOI: 10.1016/j.celrep.2019.08.090
  • 49. Liu, Jun; Gao, Ming; Nipper, Michael; Deng, Janice; Sharkey, Francis E; Johnson, Randy L; Crawford, Howard C; Chen, Yidong; Wang, Pei. Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption. PLoS Biol. 2019 Sep 12;17(9):e3000418. PMID: 31513574 PMCID: PMC6742234 DOI: 10.1371/journal.pbio.3000418
  • 50. Stone ML, Beatty GL. Cellular determinants and therapeutic implications of inflammation in pancreatic cancer. Pharmacol Ther. 2019 Sep;201:202-213. PMID: 31158393 PMCID: PMC6708742 DOI: 10.1016/j.pharmthera.2019.05.012
  • 51. Dougan, Stephanie K; Dougan, Michael. SMAC mimetics throw a molecular switch to control TH17 responses. Sci Signal. 2019 Aug 27;12(596):eaay3986. PMID: 31455724 DOI: 10.1126/scisignal.aay3986
  • 52. Goyal, Lipika; Shi, Lei; Liu, Leah Y; Fece de la Cruz, Ferran; Lennerz, Jochen K; Raghavan, Srivatsan; Leschiner, Ignaty; Elagina, Liudmila; Siravegna, Giulia; Ng, Raymond W S; Vu, Phuong; Patra, Krushna C; Saha, Supriya K; Uppot, Raul N; Arellano, Ron; Reyes, Stephanie; Sagara, Takeshi; Otsuki, Sachie; Nadres, Brandon; Shahzade, Heather A; Dey-Guha, Ipsita; Fetter, Isobel J; Baiev, Islam; Van Seventer, Emily E; Murphy, Janet E; Ferrone, Cristina R; Tanabe, Kenneth K; Deshpande, Vikram; Harding, James J; Yaeger, Rona; Kelley, Robin K; Bardelli, Alberto; Iafrate, A John; Hahn, William C; Benes, Cyril H; Ting, David T; Hirai, Hiroshi; Getz, Gad; Juric, Dejan; Zhu, Andrew X; Corcoran, Ryan B; Bardeesy, Nabeel. TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma. Cancer Discov. 2019 Aug;9(8):1064-1079. PMID: 31109923 PMCID: PMC6677584 DOI: 10.1158/2159-8290.CD-19-0182
  • 53. Halbrook CJ1, Crawford HC2,3,4. Hiding in plain sight. Science. 2019 Jun 21;364(6446):1132-1133. PMID: 31221844 PMCID: PMC6709523 DOI: 10.1126/science.aax9341
  • 54. Aguirre AJ. Oncogenic NRG1 Fusions: A New Hope for Targeted Therapy in Pancreatic Cancer. Clin Cancer Res. 2019 Aug 1;25(15):4589-4591. Epub 2019 Jun 4. PMID: 31164372 PMCID: PMC6679796 DOI: 10.1158/1078-0432.CCR-19-1280.
  • 55. Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA. Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.Cell Metab. 2019 Jun4;29(6):1390-1399.e6. Epub 2019 Feb 28. PMID: 30827862 PMCID: PMC6602533 DOI: 10.1016/j.cmet.2019.02.001
  • 56. Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, Ferrone CR, Parikh AR, Weekes CD, Nipp RD, Kwak EL, Allen JN, Corcoran RB, Ting DT, Faris JE, Zhu AX, Goyal L, Berger DL, Qadan M, Lillemoe KD, Talele N, Jain RK, DeLaney TF, Duda DG, Boucher Y, Fernández-Del Castillo C, Hong TS. Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial. JAMA Oncol. 2019 May 30. PMID: 31145418 PMCID: PMC6547247 DOI: 10.1001/jamaoncol.2019.0892
  • 57. Amoozgar Z, Jain RK, Duda DG. Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System?. Cancer Res. 2019 May 1;79(9):2104-2106.PMID: 31043429 PMCID: PMC6601607 DOI: 10.1158/0008-5472.CAN-19-0749
  • 58. Balachandran VP, Beatty GL, Dougan SK. Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities. Gastroenterology. 2019 May;156(7):2056-2072. PMID: 30660727 PMCID: PMC6486864 DOI: 10.1053/j.gastro.2018.12.038
  • 59. Dougan M, Dranoff G, Dougan SK. GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation. Immunity. 2019 Apr 16;50(4):796-811. PMID: 30995500 DOI: 10.1016/j.immuni.2019.03.022
  • 60. Nia HT, Munn LL, Jain RK. Mapping Physical Tumor Microenvironment and Drug Delivery. Clin Cancer Res. 2019 Apr 1;25(7):2024-2026. PMID: 30630829 PMCID: PMC6445672 DOI: 10.1158/1078-0432.CCR-18-3724
  • 61. Cleary JM, Horick NK, McCleary NJ, Abrams TA, Yurgelun MB, Azzoli CG, Rubinson DA, Brooks GA, Chan JA, Blaszkowsky LS, Clark JW, Goyal L, Meyerhardt JA, Ng K, Schrag D, Savarese DMF, Graham C, Fitzpatrick B, Gibb KA, Boucher Y, Duda DG, Jain RK, Fuchs CS, Enzinger PC,. FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial. Cancer. 2019 Mar 26. PMID: 30913304 PMCID: PMC6763367 DOI: 10.1002/cncr.32029
  • 62. Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nat Biomed Eng. 2019 Mar;3(3):230-245. PMID: 30948807 PMCID: PMC6452896 DOI: 10.1038/s41551-018-0334-7
  • 63. Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L. A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. Nat Protoc. 2019 Feb;14(2):541-555. PMID: 30617350 PMCID: PMC6571021 DOI: 10.1038/s41596-018-0105-7
  • 64. Martin JD, Seano G, Jain RK. Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges. Annu Rev Physiol. 2019 Feb 10;81:505-534. PMID: 30742782 PMCID: PMC6571025 DOI: 10.1146/annurev-physiol-020518-114700
  • 65. Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, Yeku O, Del Carmen MG, Spriggs DR, Jain RK, Xu L. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2210-2219. PMID: 30659155 PMCID: PMC6369817 DOI: 10.1073/pnas.1818357116
  • 66. Whittle MC, Hingorani SR. Fibroblasts in Pancreatic Ductal Adenocarcinoma: Biological Mechanisms and Therapeutic Targets. Gastroenterology. 2019 Feb 2. pii: S0016-5085(19)30359-2. PMID: 30721663 PMCID: PMC6486863 DOI: 10.1053/j.gastro.2018.12.044
  • 67. Crawford HC, Pasca di Magliano M, Banerjee S. Signaling Networks That Control Cellular Plasticity in Pancreatic Tumorigenesis, Progression, and Metastasis. Gastroenterology. 2019 Feb 1. pii: S0016-5085(19)30351-8. PMID: 30716326 PMCID: PMC6545585 DOI: 10.1053/j.gastro.2018.12.042
  • 68. Wen HJ, Gao S, Wang Y, Ray M, Magnuson MA, Wright CVE, Di Magliano MP, Frankel TL, Crawford HC. Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;8(2):173-192. PMID: 31125624 PMCID: PMC6661420 DOI: 10.1016/j.jcmgh.2019.05.006
  • 69. Chen IX, Chauhan VP, Posada J, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK. Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer. Proc Natl Acad Sci U S A. 2019 Jan 30. pii: 201815515. PMID: 30700545 PMCID: PMC6410779 DOI: 10.1073/pnas.1815515116
  • 70. Datta M, Coussens LM, Nishikawa H, Hodi FS, Jain RK. Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies. Am Soc Clin Oncol Educ Book. 2019 Jan;39:165-174. PMID: 31099649 PMCID: PMC6596289 DOI: 10.1200/EDBK_237987
  • 71. Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018 Dec 18;49(6):1148-1161.e7. PMID: 30552023 PMCID: PMC6301092 DOI: 10.1016/j.immuni.2018.09.024
  • 72. Aguirre AJ. Refining Classification of Pancreatic Cancer Subtypes to Improve Clinical Care. Gastroenterology. 2018 Dec;155(6):1689-1691. PMID: 30419209 DOI: 10.1053/j.gastro.2018.11.004
  • 73. Goggins MG, Lippman SM, Constantinou PE, Jacks T, Petersen GM, Syngal S, Maitra A. Intercepting Pancreatic Cancer: Our Dream Team's Resolve to Stop Pancreatic Cancer. Pancreas. 2018 Nov/Dec;47(10):1175-1176. PMID: 30325853 PMCID: PMC6193263 DOI: 10.1097/MPA.0000000000001165
  • 74. Yasmin-Karim S, Bruck PT, Moreau M, Kunjachan S, Chen GZ, Kumar R, Grabow S, Dougan SK, Ngwa W. Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer. Front Immunol. 2018 Sep 7;9:2030. PMID: 30245691 PMCID: PMC6137176 DOI: 10.3389/fimmu.2018.02030
  • 75. Khandekar MJ, Jain R. Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study. Transl Cancer Res. 2018 Feb;7(Suppl 1):S16-S20. PMID: 30175050 PMCID: PMC6117158 DOI: 10.21037/tcr.2017.12.17
  • 76. Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D, McDannold N, Jain RK. Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8717-E8726. PMID: 30150398 PMCID: PMC6140479 DOI: 10.1073/pnas.1807105115
  • 77. Aguirre AJ, Nowak JA, Camarda ND, Moffitt RA, Ghazani AA, Hazar-Rethinam M, Raghavan S, Kim J, Brais LK, Ragon D, Welch MW, Reilly E, McCabe D, Marini L, Anderka K, Helvie K, Oliver N, Babic A, Da Silva A, Nadres B, Van Seventer EE, Shahzade HA, St Pierre JP, Burke KP, Clancy T, Cleary JM, Doyle LA, Jajoo K, McCleary NJ, Meyerhardt JA, Murphy JE, Ng K, Patel AK, Perez K, Rosenthal MH, Rubinson DA, Ryou M, Shapiro GI, Sicinska E, Silverman SG, Nagy RJ, Lanman RB, Knoerzer D, Welsch DJ, Yurgelun MB, Fuchs CS, Garraway LA, Getz G, Hornick JL, Johnson BE, Kulke MH, Mayer RJ, Miller JW, Shyn PB, Tuveson DA, Wagle N, Yeh JJ, Hahn WC, Corcoran RB, Carter SL, Wolpin BM. Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine. Cancer Discov. 2018 Sep;8(9):1096-1111. PMID: 29903880 PMCID: PMC6192263 DOI: 10.1158/2159-8290.CD-18-0275
  • 78. Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RK. Quantifying solid stress and elastic energy from excised or in situ tumors. Nat Protoc. 2018 May;13(5):1091-1105. PMID: 29674756 PMCID: PMC6546092 DOI: 10.1038/nprot.2018.020
  • 79. Carr JA, Franke D, Caram JR, Perkinson CF, Saif M, Askoxylakis V, Datta M, Fukumura D, Jain RK, Bawendi MG, Bruns OT. Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4465-4470. PMID: 29626132 PMCID: PMC5924901 DOI: 10.1073/pnas.1718917115
  • 80. Pinter M, Kwanten WJ, Jain RK. Renin-Angiotensin System Inhibitors to Mitigate Cancer Treatment-Related Adverse Events. Clin Cancer Res. 2018 Aug 15;24(16):3803-3812. PMID: 29610292 PMCID: PMC6095804 DOI: 10.1158/1078-0432.CCR-18-0236
  • 81. Stylianopoulos T, Munn LL, Jain RK. Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. Trends Cancer. 2018 Apr;4(4):292-319. PMID: 29606314 PMCID: PMC5930008 DOI: 10.1016/j.trecan.2018.02.005
  • 82. Puré E, Hingorani SR. Mesenchymal Cell Plasticity and Perfidy in Epithelial Malignancy. Trends Cancer. 2018 Apr;4(4):273-277. PMID: 29606311 DOI: 10.1016/j.trecan.2018.02.007
  • 83. Stylianopoulos T, Munn LL, Jain RK. Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy. Trends Cancer. 2018 Apr;4(4):258-259. PMID: 29606306 PMCID: PMC6161778 DOI: 10.1016/j.trecan.2018.02.010
  • 84. Jain RK, Batista A. A Physical View of Cancer. Trends Cancer. 2018 Apr;4(4):257. PMID: 29606305 PMCID: PMC6296379 DOI: 10.1016/j.trecan.2018.03.001
  • 85. Halbrook CJ, Pasca di Magliano M, Lyssiotis CA. Tumor cross-talk networks promote growth and support immune evasion in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G27-G35. PMID: 29543507 PMCID: PMC6109710 DOI: 10.1152/ajpgi.00416.2017
  • 86. Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK. Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat Rev Clin Oncol. 2018 May;15(5):325-340. PMID: 29508855 PMCID: PMC5921900 DOI: 10.1038/nrclinonc.2018.29
  • 87. Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH, Ploegh HL, Dougan SK. Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1-Specific VHHs. Cancer Immunol Res. 2018 Apr;6(4):389-401. PMID: 29459478 PMCID: PMC6079513 DOI: 10.1158/2326-6066.CIR-17-0495
  • 88. Zhao Y, Liu P, Zhang N, Chen J, Landegger LD, Wu L, Zhao F, Zhao Y, Zhang Y, Zhang J, Fujita T, Stemmer-Rachamimov A, Ferraro GB, Liu H, Muzikansky A, Plotkin SR, Stankovic KM, Jain RK, Xu L. Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2077-E2084. PMID: 29440379 PMCID: PMC5834719 DOI: 10.1073/pnas.1719966115
  • 89. Zhang N, Chen J, Ferraro GB, Wu L, Datta M, Jain RK, Plotkin SR, Stemmer-Rachamimov A, Xu L. Anti-VEGF treatment improves neurological function in tumors of the nervous system. Exp Neurol. 2018 Jan;299(Pt B):326-333. PMID: 28911884 DOI: 10.1016/j.expneurol.2017.09.008
  • 90. Pinter M, Weinmann A, Wörns MA, Hucke F, Bota S, Marquardt JU, Duda DG, Jain RK, Galle PR, Trauner M, Peck-Radosavljevic M, Sieghart W. Use of inhibitors of the renin-angiotensin system is associated with longer survival in patients with hepatocellular carcinoma. United European Gastroenterol J. 2017 Nov;5(7):987-996. PMID: 29163965 PMCID: PMC5676550 DOI: 10.1177/2050640617695698
  • 91. Mitchell MJ, Jain RK, Langer R. Engineering and physical sciences in oncology: challenges and opportunities. Nat Rev Cancer. 2017 Nov;17(11):659-675. PMID: 29026204 PMCID: PMC5683724 DOI: 10.1038/nrc.2017.83
  • 92. Pinter M, Jain RK. Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy. Sci Transl Med. 2017 Oct 4;9(410). pii: eaan5616. PMID: 28978752 PMCID: PMC5928511 DOI: 10.1126/scitranslmed.aan5616
  • 93. Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, Ryan DP, Deshpande V, Lillemoe KD, Fernandez-Del Castillo C, Downes M, Evans RM, Michaelson J, Ferrone CR, Boucher Y, Jain RK. Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2017 Oct 1;23(19):5959-5969. PMID: 28600474 PMCID: PMC5856249 DOI: 10.1158/1078-0432.CCR-17-0256
November 1, 2021